- Endocrine Research
- Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A
-
Ko Eun Shong, Chang-Myung Oh, Jun Namkung, Sangkyu Park, Hail Kim
-
Endocrinol Metab. 2020;35(2):470-479. Published online June 24, 2020
-
DOI: https://doi.org/10.3803/EnM.2020.35.2.470
-
Correction in: Endocrinol Metab 2020;35(3):672
-
8,481
View
-
262
Download
-
21
Web of Science
-
20
Crossref
-
 Abstract
 PDF Supplementary Material PubReader  ePub
- Background
Obesity is defined as excessive fat mass and is a major cause of many chronic diseases such as diabetes, cardiovascular disease, and cancer. Increasing energy expenditure and regulating adipose tissue metabolism are important targets for the treatment of obesity. Serotonin (5-hydroxytryptophan [5-HT]) is a monoamine metabolite of the essential amino acid tryptophan. Here, we demonstrated that 5-HT in mature adipocytes regulated energy expenditure and lipid metabolism.
Methods
Tryptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme during 5-HT synthesis in non-neural peripheral tissues. We generated adipose tissue-specific Tph1 knockout (Tph1 FKO) mice and adipose tissue-specific serotonin receptor 2A KO (Htr2a FKO) mice and analyzed their phenotypes during high-fat diet (HFD) induced obesity.
Results
Tph1 FKO mice fed HFD exhibited reduced lipid accumulation, increased thermogenesis, and resistance to obesity. In addition, Htr2a FKO mice fed HFD showed reduced lipid accumulation in white adipose tissue and resistance to obesity.
Conclusion
These data suggest that the inhibition of serotonin signaling might be an effective strategy in obesity.
-
Citations
Citations to this article as recorded by  - Gut microbiota dysbiosis and decreased levels of acetic and propionic acid participate in glucocorticoid-induced glycolipid metabolism disorder
Qin Zhang, Gaopeng Guan, Jie Liu, Wenmu Hu, Ping Jin, Yung-Fu Chang
mBio.2024;[Epub] CrossRef - The Chain-Mediating Effect of Obesity, Depressive Symptoms on the Association between Dietary Quality and Cardiovascular Disease Risk
Shuai Zhang, Limei E, Zhonghai Lu, Yingying Yu, Xuebin Yang, Yao Chen, Xiubo Jiang
Nutrients.2023; 15(3): 629. CrossRef - Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone
Petra Baković, Maja Kesić, Darko Kolarić, Jasminka Štefulj, Lipa Čičin-Šain
International Journal of Molecular Sciences.2023; 24(3): 2169. CrossRef - Linking serotonin homeostasis to gut function: Nutrition, gut microbiota and beyond
Lili Jiang, Dandan Han, Youling Hao, Zhuan Song, Zhiyuan Sun, Zhaolai Dai
Critical Reviews in Food Science and Nutrition.2023; : 1. CrossRef - Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding
Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard
Frontiers in Immunology.2023;[Epub] CrossRef - The role of serotonin in prenatal ontogenesis
Inna I. Evsyukova
Journal of obstetrics and women's diseases.2023; 72(4): 81. CrossRef - Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A
Xinyang Zhang, Bohan Cheng, Yanyan Ma, Yumeng Liu, Ning Wang, Hui Zhang, Yumao Li, Yuxiang Wang, Peng Luan, Zhiping Cao, Hui Li
Biochemical and Biophysical Research Communications.2022; 587: 131. CrossRef - Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
Marina Horvatiček, Maja Perić, Ivona Bečeheli, Marija Klasić, Maja Žutić, Maja Kesić, Gernot Desoye, Sandra Nakić Radoš, Marina Ivanišević, Dubravka Hranilovic, Jasminka Štefulj
Biomedicines.2022; 10(2): 467. CrossRef - Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease
Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jin Hee Ahn
European Journal of Medicinal Chemistry.2022; 239: 114517. CrossRef - Serotonin in the regulation of systemic energy metabolism
Joon Ho Moon, Chang‐Myung Oh, Hail Kim
Journal of Diabetes Investigation.2022; 13(10): 1639. CrossRef - Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs
Natosha M. Mercado, Guanglin Zhang, Zhe Ying, Fernando Gómez-Pinilla
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2022; 1868(11): 166491. CrossRef - Modulation of adipose tissue metabolism by microbial-derived metabolites
Wenyun Liu, Ge Yang, Pinyi Liu, Xin Jiang, Ying Xin
Frontiers in Microbiology.2022;[Epub] CrossRef - Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Renal Impairment in Obese Mice
Hsiao-Pei Tsai, Po-Hsun Hou, Frank-Chiahung Mao, Chia-Chia Chang, Wei-Cheng Yang, Ching-Feng Wu, Huei-Jyuan Liao, Tzu-Chun Lin, Lan-Szu Chou, Li-Wei Hsiao, Geng-Ruei Chang
International Journal of Molecular Sciences.2021; 22(1): 409. CrossRef - Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity
Xing Ming, Arthur C.K. Chung, Dandan Mao, Huanyi Cao, Baoqi Fan, Willy K.K. Wong, Chin Chung Ho, Heung Man Lee, Kristina Schoonjans, Johan Auwerx, Guy A. Rutter, Juliana C.N. Chan, Xiao Yu Tian, Alice P.S. Kong
Diabetes.2021; 70(1): 119. CrossRef - Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease
Eun Jung Bae, Won Gun Choi, Haushabhau S. Pagire, Suvarna H. Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn
Journal of Medicinal Chemistry.2021; 64(2): 1037. CrossRef - A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis
Suhyeon Park, Yumin Kim, Jibeom Lee, Jeong Yun Lee, Hail Kim, Sunjae Lee, Chang-Myung Oh
International Journal of Molecular Sciences.2021; 22(5): 2452. CrossRef - Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis
Maja Kesić, Petra Baković, Ranko Stojković, Jasminka Štefulj, Lipa Čičin-Šain
International Journal of Molecular Sciences.2021; 22(10): 5400. CrossRef - The Mechanism of Secretion and Metabolism of Gut-Derived 5-Hydroxytryptamine
Ning Liu, Shiqiang Sun, Pengjie Wang, Yanan Sun, Qingjuan Hu, Xiaoyu Wang
International Journal of Molecular Sciences.2021; 22(15): 7931. CrossRef - Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance
Won Gun Choi, Wonsuk Choi, Tae Jung Oh, Hye-Na Cha, Inseon Hwang, Yun Kyung Lee, Seung Yeon Lee, Hyemi Shin, Ajin Lim, Dongryeol Ryu, Jae Myoung Suh, So-Young Park, Sung Hee Choi, Hail Kim
Journal of Clinical Investigation.2021;[Epub] CrossRef - Serotonergic Regulation of Hepatic Energy Metabolism
Jiwon Park, Wooju Jeong, Chahyeon Yun, Hail Kim, Chang-Myung Oh
Endocrinology and Metabolism.2021; 36(6): 1151. CrossRef
|
KES
